Men and women have different genetic predispositions

Barcelona

A research team from the University Barcelona and the Biomedical Research Center Network Mental health (CIBERSAM) confirmed the presence of the vulnerability genetics different in men And women regarding schizophrenia and other mental disorders.

In particular, this pioneering work, published in the journal European Neuropsychopharmacology, highlights that this burden genetics has more weight V men what’s in womenThe University announced this Thursday Barcelona.

Genetics

researchers They analyzed a sample from CIBERSAM, which included 1826 patients with psychosis and 1372 controls.

The goal was to analyze such as polygenic scales (PGS) for schizophrenia, mess bipolar and mess major depressive disorder contribute to the risk of developing psychotic disorders and, based on this, establish how these associations differ between men And women.

“Our results reinforce the hypothesis that there are common genetic factors that contribute to the risk of developing these diseases, suggesting that there is a common biological basis between them.”

Genetics of men and women

He explained first author studio, who is a member of the department Geneticsmicrobiology and statistics at the University Barcelona (UB) and Sant Joan de Déu Hospital BarcelonaMarina Mityans.

Likewise, the results of this study indicate that there are differences between men And women in vulnerability genetics to psychotic disorders, which may have important implications for understanding sex differences observed in prevalence, clinical presentation, and response to treatment.

• “Our study highlights the importance of considering gender differences in genetic research to develop more personalized strategies for prevention, diagnosis and treatment in clinical practice.”

Employee of the Department of Evolutionary Biology, Ecology and Environmental Management, URB and chief co-investigator from the group G08 CIBERSAM, Barbara Arias. EFE