Aspirin may play key role in cancer treatment
Their names are Anais Elevout and Guillem Estivill. They are 29 and 28 years old respectively. One from Malaga, the other from Barcelona. Together they discovered through experiments on mice andthe strength of some anti-inflammatory drugs such as aspirinto increase immunotherapy
And this is its importance. Cancer occurs when the cells multiply randomly and uncontrollably and manage to evade the immune system.that if she is weakened, she does not recognize them as a threat and does not fight them
Both researchers discovered a crucial element in activation of malignant T lymphocytes: Monocytes, another type of white blood cell produced in the bone marrow. They noticed that monocytes travel through the blood and can capture fragments of cancer cells, showing them to T cells so they can reactivate and attack the tumor.
The Vienna group argues that anti-inflammatory drugs cyclooxygenase inhibitorslike aspirin, are a “promising strategy” to improve the effectiveness of immunotherapy because they block the production of inflammatory molecules such as prostaglandin E2.
And not only aspirin, but also other anti-inflammatory drugs, such as ibuprofen, or those taken for pain. According to these researchers, patients who consume them have a better response, as observed in immunotherapy clinical trials.
What is the dose of aspirin or ibuprofen against cancer?
According to a biologist from Barcelona, these anti-inflammatory drugs provide short-term benefit to cancer patients because reduce disease progressionalthough over time the tumor appears again. For this reason, they offer various combinations of immunotherapy, anti-inflammatory drugs at appropriate doses, and other types of interferon-inducing drugs. So far, the discovery has worked in mice. And they have demonstrated this in melanoma, pancreatic, lung and colon cancers. But we’ll have to see if it works in humans too, and that would be a big achievement.
But what dose of aspirin or ibuprofen will be needed? Treatment should be adjusted, keeping in mind the side effects of these drugs, such as digestive problems or cardiovascular disease. Therefore, it will be necessary to combine them with other drugs.
Two Spanish scientists work at the Research Institute for Molecular Pathology in Vienna (Austria) under the direction of biologist Anna Obenauf. Their research was published this Wednesday in the journal Nature, a guide to the world’s top scientists.
The human body’s defenses, white blood cells, are formed inside the bones, but some are sent to the thymus, a small gland in the chest, to mature and become cytotoxic T lymphocytes, which can destroy cells infected by viruses or bacteria.
We shouldn’t forget this Aspirin by itself does not cure cancer. This is one option, but there are more similar drugs. and even more powerful ones that also have anti-inflammatory effects and can be used. Ideally, combination therapy
This is a rigorous and encouraging study, but it should be treated with caution. We will see the results of combining anti-inflammatory drugs with the most common immunotherapies, such as so-called immune checkpoint inhibitors.
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