Could hemodiafiltration become the new standard in renal replacement therapy?

chronic kidney disease It is a serious global health challenge, as it is estimated affects 830 million people around the world, of which Nearly four million people depend on dialysis When renal replacement therapy is needed. now one international essayDone by Convince Consortium and operated by the University Medical Center (UMC) Utrecht, have concluded He death rate between kidney failure patients can be reduced by using high volume hemodiafiltration technique Compared to those treated with high-flux hemodialysis, it is most commonly used.

Total included in the study 1,360 patients out of 61 centers of eight european countriesfor which it was carried out follow up for an average of 30 months, Of these, 683 received thrice-weekly high-volume hemodiafiltration and 677 received high-flux hemodialysis. rate of death rate There were 7.1 deaths per 100 patient-years in the randomized hemodiafiltration group, compared with 9.2 deaths per 100 patient-years in the hemodialysis group, which corresponds to Relative reduction of 23%.

Traditional high-throughput hemodialysis, which uses diffusion to remove small molecules and fluid from the blood, represents the most prevalent form of dialysis for the treatment of kidney failure. for his part, hemodiafiltration The high-volume machine incorporates technologies from both Diffusion as Convection To remove large molecules and manage fluid replacement by convection.

Principal Investigator of the Study, to Professor peter blankestijnfrom UMC Utrecht, “The results clearly demonstrate survival benefit Using hemodiafiltration versus hemodialysis in the treatment of kidney failure resulted in a significant 23% reduction in all-cause mortality. I’m optimistic that hemodiafiltration can become new standard of meditation”.

The CONVINCE trial was led by researchers from UMC Utrecht, in collaboration with University College London (UCL), Charite Universitätsmedizin Berlin, University of Bari, The George Institute for Global Health, Imperial College London and dialysis providers Fresenius Medical Care, Diaverum & B. Braun Avitum.

– To date, 33 associations dedicated to kidney failure are already active members of Somos Pacientes. and yours?

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