They discovered a new syndrome associated with COVID-19

Researchers from the University of San DiegoUSA), together with experts from Great Britainthey are researching the syndrome border to coronavirus after seeing that some patients had a very rare autoimmune disease called MDA5: dermatomyositis (DM) associated with autoantibodies in patients, They may or may not have contracted the disease..

Specifically, the researchers wanted to know if there was a link between MDA5-positive dermatomyositis and COVID-19. “DM is more common in people of Asian descent, especially Japanese and Chinese.“, indicates that Pradipta Ghosh.

Aspects to consider

However, the doctor McGonagle note the explosive trend among Caucasians. “BoNE was created to ignore factors that differentiate patients in the group upon detection selectively

something that is common (shared) among all members of the group,” he points out. Ghosh.

Previous BoNE applications allowed Ghosh and his team to identify other pulmonary and cardiac syndromes associated with COVID (infectious disease caused by the SARS-CoV-2 virus) in adults and childrenrespectively.

It’s because of this Ghosh and Dennis McGonagleProfessor of Research Rheumatology at University of Leeds in the United Kingdom they formed a team to investigate what they discovered. Yes, it really was a syndrome brand new.

Step by step

The research began with the discovery in McGonagle’s laboratory autoantibodies against MDA5an RNA sensor enzyme whose functions include detecting COVID-19 and other RNA viruses. Just 25 patients out of a group of 60 developed scarring in the lungs, better known as interstitial lung disease.

Ghosh indicated that the scars on the lungs were serious enough to cause the death of eight people group due to progressive fibrosis. Additionally, he said there are established clinical profiles for MDA5 autoimmune diseases.

The UC San Diego team and Ghosh examined McGonagle’s data using BoNE.. Thus, they found that patients who showed the highest levels of MDA5 response also showed high levels interleukin-15.

conclusions

“Interleukin-15 is a cytokine that can cause two main types of immune cells. They can push cells to the brink of exhaustion and create an immune phenotype that is very often considered a sign progressive interstitial lung disease or pulmonary fibrosis“, he details.

BoNE allowed team to determine the cause of the syndrome Yorkshire and identify a specific single nucleotide polymorphism that has a protective effect. By right of discoverythe group was able to name the disease: MDA5 autoimmunity and modern interstitial pneumonitis with COVID-19.

In short, MIP-S.. “Pronounced “meepsy”Gosha clarified. And he added that the name was invented establish a connection with MIS-C, separate childhood illness associated with COVID.

Against this backdrop, Ghosh assures that it is extremely unlikely that MIP-C will be limited to the UK. In fact, reports of symptoms

MIP-Cs originate from every. Identification of interleukin-15 as a causal link hopes that stimulate treatment research.

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