A global genetic alert system is key to preventing the next pandemic.

Optimization of WGS (Whole Genome Sequencing) technology This could be key to preventing the next pandemic. This is according to a group of microbiologists affiliated with the European Society for Clinical Microbiology ESCMID, in the paper “Real-time genomic surveillance to enhance surveillance of infectious diseases and antimicrobial resistance,” which was recently published in the journal Frontiers in Science. Researchers suggest that Through genomic analysis of microbial pathogens with epidemic potential, early detection of outbreaks and control of epidemics caused by various pathogens and AMR can be achieved.

The paper, whose principal investigator is Mark Strullens, former chief microbiologist at ECDC, states: “mobilize genomic pathogen surveillance to contain and mitigate health threats posed by infectious diseases and antimicrobial resistance (AMR), building on advances made through large-scale genome sequencing, SARS-CoV-2 variant analysis to guide monitoring and public attention to Covid-19.“

As the article explains, there are currently two major public health threats that also overlap: emerging infectious diseases from zoonoses and increasing microbial resistance. Both threats can only be addressed through a One Health approach, based on the recognition that human health depends on the health of the ecosystem.

“As national, regional and global institutions build stronger pandemic preparedness systems in the wake of the COVID-19 pandemic, These efforts will greatly benefit from increased pathogen sequencing capabilities and laboratory expertise in low-, middle-, and high-income countries.“, say the researchers.

Real-time genomic surveillance based on this approach could enable the rapid discovery of new strains of resistant bacteria. This information, in turn, “It can inform vaccination campaigns, develop specific treatments, and guide public health responses.“

Likewise, WGS technologies can help improve the understanding of certain diseases and identify possible countermeasures.

To achieve these goals, the article raises several issues, such as the need to “advance the standardization of pathogen genomic nomenclature, surveillance and database interoperability, international agreements and cross-sector collaboration should promote good governance based on consensus compatible with.” national legislation and FAIR and is responsible for data exchange within and between surveillance networks and health authorities.”

They also assure that “evaluating the cost-effectiveness of genomic surveillance in reducing the burden of disease will help support demands for data collection and sharing to demonstrate overall health and economic benefits.”

All of this should come together, as they explain in the paper, “at the onset of large-scale genomic surveillance of major human and zoonotic pathogens, which will improve our global epidemic information and help reduce future pandemics.”