a group of scientists discover new clues

Given the recent emergence of a COVID variant known as Pirola, many people have become infected again. Many others who even contracted the virus have now done so with a new wave of cases. According to the latest report from the Surveillance System for Severe Acute Respiratory Infections (siVIRA)Hospital positivity rose nine points to 33%. In fact, experts note that Pirola, a subvariant of Omicron, was responsible for almost 60% of infections reported in recent weeks. Despite this, still There are people who have never had COVID. in a world that has come to a complete standstill with the advent of this epidemic. They do not know the symptoms of the virus first hand and have not experienced the many effects it causes. After an exhaustive scientific study, a team of researchers discovered new evidence supporting their immunity.

More information about COVID infections

COVID is still present in our lives. In fact, within weeks, Spain has seen a wave of infections that has risen by 33%. According to the Acute Respiratory Infections Surveillance System (Sivira), Virus cases in Spain have quadrupled in just one month. Concern about this new wave of infections has reached the most vulnerable in the population. Patients with chronic or respiratory diseases, the elderly and those with other health problems strictly follow the recommendations of specialists to avoid infection. On the opposite side of the population are those who, despite the lack of any measures, have not contracted COVID. Although this is a surprising and unusual phenomenon, There are still people who have never been sickor. These people have lived normally for the past four years since the start of the COVID-19 pandemic. They were not suffering from symptoms of the virus and were unaware of its effects, although they were likely to be close to friends or relatives who were infected.

For this reason, a team of researchers from the Wellcome Trust Sanger Institute, University College (UCL) and Imperial College London conducted a study to find an answer that scientifically substantiates this unusual fact. The study, “Human SARS-CoV-2 Infection Revealing Local and Systemic Response Dynamics,” published in Nature, sampled 16 healthy adult volunteers with no history of COVID who were administered the SARS-CoV-2 virus through the nose. . . Then research led by Rick Lindeboom, Marko Nikolic and Sarah Teichmann studied the immune responses against infection of all and each of the infected patients. To do this, those responsible for the study monitored the blood, nasal mucosa and immune cell activity compared to the moment before infection. In addition, teams from the Wellcome Sanger Institute and UCL used single-cell sequencing to create a dataset of more than 600,000 individual cells.

New output

As the study found, “seven participants remained PCR negative throughout the quarantine period, indicating that these individuals successfully prevented the occurrence of persistent or transient infection.” That is, surprisingly, These patients were free of disease. Through data collected from 16 volunteers in the study, scientists discovered unique immune responses associated with resistance to viral infections and diseases. The volunteers’ response led to the activation of specialized mucosal immune cells in the blood and a decrease in the number of inflammatory white blood cells that normally destroy pathogens. According to a study published in the journal Nature, volunteers who eliminated the virus from their bodies did not show a typical immune response, but they developed much more subtle innate responses that had not been seen before. They also did not show the usual symptoms that other infected people usually suffer from. According to the researchers, high levels of HLA-DQA2 gene activity before infection helped people prevent long-term infection.

Of these ten people who did not develop persistent infection, three had “transient” infection, characterized by intermittent positive viral tests on nasal swabs. Seven of them developed what researchers call an “abortion” infection, characterized by a lack of positive tests for the virus. The remaining six volunteers developed persistent COVID infection. showed a rapid immune response in the blood, but a slower immune response in the nose, which allowed the virus to establish itself there. Despite some differences in infection outcomes, the study found that All participants had similar gene expression signatures related to early activation of the innate immune response.

“During persistent infections leading to COVID-19, we observed a new and immediate APR in ciliated cells at the site of infection. In addition, we found a distinct cellular state for T cells. activated common cells containing SARS-CoV-2-specific TCRs, and we demonstrate that this signature can be projected onto patient cohort data. to identify disease-specific T cell responsesThe study provides “a complete and detailed time-resolved description of the course of mild SARS-CoV-2 infection or any other infectious disease,” the study said. New insights into “responses associated with resistance to persistent infection and disease “