According to the study, these are the antidepressants that cause the most obesity.

The results showed that bupropion users gained less weight compared to other drugs.

Patients and their doctors often have several options when they first start taking an antidepressant, so the study provides important evidence about how much weight gain to expect after starting some of them. the most common antidepressants.

And new evidence published Annals of Internal Medicine A comparison of weight gain among eight different first-line antidepressants found that users bupropion have between 15% and 20% less likely to gain a certain amount of weight. It is clinically significant that users sertralinethe most common drug.

New results obtained by researchers from Harvard Pilgrim Health Institute (USA)found which common antidepressants cause the most and least weight gain after starting the medications.

Lead Author, Joshua PetimarAssociate Professor of Community Medicine at Harvard Medical School and the Harvard Pilgrim Institute for Health Sciences, added that “doctors and patients can use this information, among other factors, to help decide which option is right for them.”

The researchers used prescription data electronic health records from eight U.S. health systems participating in PCORnet, the National Patient-Oriented Clinical Research Network, to conduct a study using data from 183,118 adults aged 18 to 80 who were new users of antidepressants. Although randomized controlled trials is considered the most rigorous method Comparing the effects of different drugs is prohibitively expensive and time-consuming. In this case, the research team simulated a randomized trial by designing an ideal hypothetical study and making the data as close to that study as possible.

The researchers compared weight at 6, 12, and 24 months after starting treatment with eight common antidepressants: sertraline, citalopram, escitalopram, fluoxetine, paroxetine, bupropion, duloxetine, and venlafaxine.

The results showed that users bupropion gained the least weight compared with users of other antidepressants. Bupropion users were about 15 to 20 percent less likely to gain clinically significant weight than those taking a more commonly used drug. sertraline. The researchers considered a weight gain of 5% or more to be clinically significant. The results also showed that a large percentage of patients were taking medications that caused more weight gain than commonly available alternatives in the same class or subclass.

For example, sertraline, escitalopram and paroxetine are selective serotonin reuptake inhibitors (SSRIs), the most common type of antidepressant, but escitalopram and paroxetine were each associated with about a 15% higher risk of clinically significant weight gain than sertraline in the first 6 months.

“While there are several reasons why patients and their doctors may prefer one antidepressant over another, weight gain is the primary side effect that often leads patients to stop taking their medications,” says lead author Jason Block, MD, an assistant professor of community medicine at Harvard Medical School and the Harvard Pilgrim Health Institute.

Sertraline

Sertraline is used for treat depression, obsessive-compulsive disorder (annoying thoughts that don’t go away and the need to do certain things over and over again), panic attacks (sudden, unexpected attacks of intense fear and anxiety about these attacks), Post-traumatic stress disorder (anxious psychological symptoms that develop after a frightening experience) and social anxiety disorder (an extreme fear of interacting with or acting in front of other people that interferes with normal functioning). It is also used to relieve symptoms of premenstrual dysphoric disorder, including mood changes, irritability, bloating, and breast tenderness. It belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural chemical in the brain that helps maintain mental balance.

Bupropion

A medicine used for treat depression and other disorders. It is also used to help people quit smoking. Bupropion hydrochloride increases levels of the chemicals dopamine, serotonin, and norepinephrine in the brain. This helps improve mood and reduce cravings for nicotine. It is a type of antidepressant and nicotine receptor antagonist. Also called Wellbutrin and Zyban.