Human papillomavirus infection and cardiovascular mortality

Introduction

cardiovascular diseases (CVDs) are the leading cause of death worldwide, accounting for approximately 17.9 million deaths in 2019 (32% of all deaths worldwide), and this number is projected to increase to 23.6 million by 2030. Cardiovascular disease risk factors such as smoking, dyslipidemia, high blood pressure and diabetes, cardiovascular disease remains a leading cause of death and disability. Moreover, only these traditional risk factors they don’t explain

completely high incidence and prevalence of cardiovascular diseases, since approximately In 20% of cases of cardiovascular disease, these traditional risk factors are absent.. Thus, identifying non-traditional modifiable CVD risk factors is critical for developing optimal prevention and treatment strategies to reduce CVD.

He human papilloma virus (HPV) is a sexually transmitted infection whose prevalence in the general female population ranges from 2% to 44%. Strains high-risk HPV infection (HR-HPV) are well-known causative agents of anogenital cancer in women. Several cross-sectional studies have suggested a possible association between HR-HPV and atherosclerotic cardiovascular disease (ASCVD). Our recent prospective cohort study confirms this association with new-onset cardiovascular disease. However, no cohort studies have assessed long-term cardiovascular outcomes associated with HR-HPV infection.

Understanding the contribution of HR-HPV infection to long-term cardiovascular outcomes in women with HPV may have important clinical implications, especially given the availability of HPV vaccines. Therefore, we conducted a large cohort study of Korean women tested for HR-HPV as part of a health screening program to test our hypothesis that HR-HPV infection in women is associated with increased cardiovascular mortality, with possible effect modification. on obesity.

Background and goals

Infection through high-risk human papillomavirus (HR-HPV), a well-known risk factor for cervical cancer, is associated with cardiovascular disease (CVD). However, its association with cardiovascular mortality remains uncertain. This study examined the association between HR-HPV infection and cardiovascular mortality.

Methods

As part of a medical examination 163,250 women CVD-free Korean women (mean age: 40.2 years) were screened for HPV-HPV and followed for up to 17 years (median: 8.6 years).

National mortality registries have identified deaths from cardiovascular disease. Hazard ratios (HRs) and 95% confidence intervals (CIs) for cardiovascular mortality were estimated using Cox proportional hazards regression analysis.