Categories: Health

IkBα, a protein that opens the door to creating blood stem cells in the laboratory.

Until now, obtaining hematopoietic stem cells in the laboratory was impossible. A study published in the journal Nature Communications shows the role Ikbα, a protein that paves the way for the regulation of stem cell-related genes.

Researchers from the Del Mar Hospital Research Institute, the Josep Carreras Leukemia Research Institute and Ciber del Cancer (Ciberonc) led Dr. Anna Bigas, were responsible for studying the possible role of IkBα, a protein involved in the regulation of stem cell-related genes.

Studying delves into the biological mechanisms that explain how protein reduces retinoic acid levels,

which is fundamental in transferring cells to a state of rest. That is, it ensures that they remain inactive and do not differentiate.

Dr. Bigas: “Activating or inhibiting IκBα may allow us to have a tool to control the characteristics of blood stem cells and make it easier for these cells to go to sleep and remain in the state in which they were created.”

The study shows that when Ikbα is eliminated, retinoic acid levels increase, cells “they are sleeping” So “We are enriching a population of cells that is usually very scarce, but performs the most primitive function of stem cells, the most conserved and persists throughout life.” Dr. Bigas noted.

However, despite the reduced number, the hematopoietic stem cells from the modified embryos still had the potential to become different cells. Moreover, upon transplantation they were activated and differentiated.

Activate or inhibit IκBα This may allow us to have a tool to control the characteristics of blood stem cells and make it easier for these cells to go to sleep and stay in the state in which they were created. In the future, we could induce the differentiation of embryonic cells into hematopoietic stem cells, prevent them from differentiating and make them available for transplantation into the patient.” Dr. Bigas explained.

However, currently the only real source for this type of treatment is donation from a healthy person. Thus, this research moves in the direction“The ultimate goal is to create hematopoietic stem cells in the laboratory so that they can be used for a variety of purposes, whether direct stem cell transplantation into leukemia patients or gene therapy treatments for other diseases.”

, – the specialist emphasized. The researchers conducted the study on mouse embryos but were optimistic about transferring them into human cells.

Source link

Admin

Share
Published by
Admin

Recent Posts

Adele Exarchopoulos: actress on the poster of L’Amour Ouf nous confi ses meilleurs secrets de beauté

Avec sa beauté naturalle et sa spontaneously very raffreyhissante, Adele Exarchopoulosnow on the movie poster…

35 minutes ago

Six foreign tourists die due to poisoning with adulterated liquor in Laos. international

Six foreign tourists have died and at least two are hospitalized in Laos after allegedly…

39 minutes ago

Seven scientific societies recommend RSV vaccination in adults.

MADRID, November 22 (EUROPE PRESS) – Seven scientific societies have submitted a document recommending vaccination…

40 minutes ago

Inditex opens a new Zara Man store in Madrid, which houses the first Zacaffé store.

Today Inditex opened its new Zara Man store, located at Calle Hermosilla, 14 in Madrid,…

46 minutes ago

“HOW TO TAKE PHOTOS AND VIDEOS ON YOUR MOBILE” – City Council of Real Sitio and Villa de Aranjuez

DIGITAL LEARNING CENTER DE ARANJUEZ STARTS WITH THE FIRST FREE COURSE: "HOW TO TAKE PHOTOS…

50 minutes ago

Hansi Flick press conference live today | Preview of Celta de Vigo

Flick ended his press conference by suggesting his team win Balaidos without Lamin Yamal, asking…

51 minutes ago