In our body, when performing “technical tasks,” many vacuum cleaners are always working. rumba which tirelessly swarm in all its corners. These rumbas, like those in our homes, are responsible for removing waste generated in the body.
Its job is to get rid of potentially toxic compounds that can damage our cells, such as virus residues from an infection or defective cells. Where do these connections go? Roombas (also known as autophagosomes) take care of this.
Are rumbass In addition to being a sophisticated purification system, they are also designed to be recycled: they are able to convert collected waste into both energy and other molecules that can be reused. This is how structures are renewed and aging slows down.
For example, if our rumba In particular, the absorption of a defective protein can lead to its breakdown into various components. In the case of protein – in amino acids. Then, like Lego pieces, these pieces can be used again to form a new protein, avoiding the need to synthesize them from scratch and saving energy.
Although these maintenance tasks are constantly performed at a low intensity, significant caloric restriction triggers the process of autophagy to obtain additional resources.
Failures in the autophagy system (due to inactivation or hyperactivation) can lead to neurodegenerative, cardiovascular, autoimmune, metabolic diseases, various types of cancer and, in particular, other problems associated with faster rates of aging.
On the contrary, and in a very simple way, science tells us that if we keep our rooms running like clockwork, we can live longer and better lives.
The easiest way to induce autophagy is through calorie restriction and exercise. But there is also research being done on how to do this using calorie restriction drugs and mimetics.
We’re talking about compounds that could theoretically mimic the antiaging effects achieved through calorie restriction, but without the need to reduce calorie intake in laboratory animals and some humans.
Some of them are of natural origin, and, among other things, this is where the fame of some well-known polyphenols, such as resveratrol, comes from. While we can’t get too excited right now and the eternal youth pill is yet to come, for now we can focus on what we know: not eating too much can be a good starting point.
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