Ramon y Cajal Hospital stimulates stem cells with INDIBA

Many patients with pathologies such as diabetic foot or vascular disease They usually have problems healing wounds. In addition, cancer patients are exposed to radiation or mastectomywhich can cause many complications.

In order to reverse this situation and improve the quality of life of patients, Bioelectromagnetism Service belonging Institute of Medical Research IRYCISbelonging University Hospital Ramon y Cajalconducted an in vitro study to analyze the effect CRET electrotherapy from INDIBA for tissue regeneration.

CRET therapy This is about physiotherapy using resistive electrical transfer method (capacitive-resistive power transmission). These treatments use radiofrequency electrical currents to generate heat in the deep tissues of the body. To do this, the resistance they provide to the passage of current is used. Thereby, CRET therapy They reach areas inaccessible to other thermophysical treatments, which only work at a local and superficial level.

“We found that cells treated with INDIBA CRET therapy under normothermic conditions responded to electrical currents, causing cell proliferation and an anti-inflammatory effect detected.”

CRET therapy from INDIBA This is a non-invasive therapy that uses 448 kHz current. Thanks to the research we have developed in IRISISwe were able to find that cells treated CRET therapy from INDIBA in conditions normothermicthat is, without raising the temperature above the physiological 37°C, they respond to electrical currents, causing cell proliferation and exhibiting an anti-inflammatory effect.

“This represents a key difference from other treatments radio frequency hyperthermia is necessary to achieve the desired effect,” explains Dr. SaludDigital. Maria Luisa Hernandez Bouletfrom the research team Bioelectromagnetism Service belonging Health Research Institute IRYCIS.

Usually, CRET therapy Used for various pathologies. sports medicine, dermatology and physiotherapy. Because of this, it was known that it could be useful for wound regeneration, but until research was done into IRISIS The potential of the therapy to treat this type of injury was not known.

At the same time, since anti-inflammatory and antifibrotic effects were found in vitro, it is possible that this therapy may be useful in inflammatory pathology And cutaneous fibrous. However, for its use in patients with these pathologies, it is necessary to conduct studies similar to the one that is currently being developed Angiology and Vascular Surgery Service.

In this method, radiofrequency current affects receptors on the cell membrane. Stimulation triggers a cascade of intracellular reactions that promote the proliferation and migration of various types of skin cells, such as mother cells, fibroblasts And keratinocytes. “In addition, we also found that these treatments modulate inflammation. All these effects will contribute to faster and more effective wound regeneration.

The aim of the in vitro study was to analyze the effect CRET electrotherapy from INDIBA for tissue regeneration. In this sense, one of the main applications of stem cell stimulation is wound regeneration. “Clinical trials of the therapy are currently underway. KRET from INDIBA in 140 patients Angiology and Vascular Surgery Servicein collaboration with Dermatologyboth Ramon y Cajal Hospitalto find out the actual volume of therapy KRET in patients with pathologies such as diabetic or vascular

This type of work can significantly improve the quality of life of patients. “Difficult-to-heal wounds cause multiple complications, decreased quality of life, psychological and social consequences for both patients and their caregivers, and incur very high direct and indirect health care costs.”

However, the effectiveness of existing therapeutic strategies is limited, and therefore research into new treatments that can treat these pathologies with better results is of particular interest. “If we were to see positive results in the clinical trial currently underway, the impact on patients would be enormous by reducing the risk of serious complications such as amputation or infection, as well as wound healing time. This will improve their quality of life and morbidity,” continues the doctor.

“Electrotherapy, such as CRET therapy, has been very little studied and its mechanisms of action are completely unknown to date.”

electrotherapy How CRET therapy They have been studied very little, and the mechanisms of their action are completely unknown today. Thanks to cooperation between IRISIS and company INDIBAwe were able to describe in detail the cellular and molecular mechanism by which CRET therapy “It exerts its effect on the underlying cells of the skin.”

However, there is still a way to go. “Clinical trials must now be completed to determine the effectiveness of this therapy in patients with tissue injuries. “If the results are positive, it could be used as a foundational adjunctive therapy in conventional clinical practice.”

Depending on the results obtained in clinical trials, if it is found that this therapy can help tissue regeneration in patients with difficult-to-heal wounds, it will be necessary Spanish Agency for Medicines and Health Products (AEMPS) approved the new indication and its use in clinical practice. Once this permission is granted, it can begin to be used in services Angiology, vascular surgery And Dermatology in normal practice.

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