These are ribavirin and remdesivir, a combination of drugs that claim to kill SARS-CoV-2.
Many factors influence child care. health. We recently celebrated four years since the declaration of a state of emergency in our country. Many infections COVID-19 and many lives left on the margins.
The disease is now much better controlled than in its infancy. Despite this, there are people who do not fully recover. In this sense, and for this more specific layer of the population, a new medicine which they say is “effective” against virus SARS-CoV-2. This is about ribavirin, broad-spectrum antiviral agent and remdesivir, an effective treatment approved against Covid-19, two drugs that claim to “quickly kill the virus when used in combination.”
Union ribavirin and remdesivir He manages to quickly destroy the virus, causing excess mutations in its genome that prevent it from reproducing effectively. “Although currently the infection SARS-CoV-2 not as serious as at the beginning of the pandemic in vulnerable patients such as with weakened immunity, important to have new drug combinations to combat it,” says a CSIC researcher from the National Center for Biotechnology (CNB-CSIC) and an IIS-FJD fellow. Celia Perales.
What is the treatment with ribavirin and remdesivir?
The study they conducted was published in a journal. British Journal of Pharmacology and shows that ribavirin And remdesivir they receive quickly destroy the virus when combined. This opens the door to new treatments for SARS-CoV-2, especially in those vulnerable patients who cannot eradicate the virus.
In this sense, CSIC researcher from the Center for Molecular Biology of Severo Ochoa (CBM-CSIC-UAM), Stephen Domingoreports the portal Infosalus, emphasizes that it was found that “these drugs manage to suppress the replication of the virus, causing an excessive number of mutations in its genome, which affect the viability of the virus.”
This mechanism, called “lethal mutagenesis”is an antiviral strategy that has proven effective against other highly variable RNA viruses.
Ribavirin and Remdesivir
ribavirin It has a nucleotide base whose components inhibit the duplication of a large number of RNA viruses, including orthomyxoviruses, paramyxoviruses, arenaviruses, bunyaviruses, herpesviruses, adenoviruses, poxviruses and retroviruses. It is quickly absorbed in the digestive tract and reaches maximum concentration after an hour and a half.
The active substance ribavirin was created to treat Hepatitis C always combined with other medications, all as prescribed by the doctor and taking into account the side effects, of which there are many.
In its turn, remdesivir This is a drug for intravenous administration, so it is indicated only for hospitalized patients with subsequent hospitalization at home or in a day hospital.
This medicine was created to fight the virus Ebola, but at the beginning of the pandemic it demonstrated effectiveness “in vitro” against Corona virus, which allowed the European Commission to grant its marketing authorization in July 2020, which was limited only to the treatment of Covid-19 in Adults And in teenagers over 12 years old with pneumonia who required oxygen.