They are developing a vaccine with promising results against brain cancer
scientific achievements are also celebrated in favor of in tests A. Messenger RNA (mRNA) vaccine that the University of Florida conducted to treat brain cancer. In the first phase 1 clinical trial in humans, the mRNA vaccine quickly reprogrammed the immune system to attack glioblastoma. the most aggressive and deadly brain tumor.
This is a light of hope that should be treated with the necessary caution in experiments of this type, especially considering that to date only was tested on four adult patients. According to the prestigious Cell review, the findings are consistent with those obtained They were taken from tests on 10 dogs suffering from the same disease. They are also similar to those observed in preclinical mouse models.
The Spaniard is part of the team
Spanish biochemist Hector Mendes, who is part of the team that developed this vaccine, knows about this type of immunotherapy. As he explained when announcing the results, researchers inject lipid particles with genetic information obtained from each patient’s tumor. This will prepare the immune system to recognize cancer cells as a threat and destroy them.
The study’s lead author, pediatric oncologist Elias Sayur, emphasizes how quickly the vaccine works. “In less than 48 hours, we were able to see these tumors go from what we call ‘cold,’ meaning with very few immune cells and a very suppressed immune response, to ‘hot,’ a very active immune response.” He says.
What is gioblastoma?
He glioblastoma It is one of the most aggressive types of cancer, with an average survival rate of about 15 months. Current standard treatment consists of surgery, radiation therapy, and some combination of chemotherapy.
This type of cancer is not the only one being treated in clinical trials with mRNA vaccines. A London hospital has begun administering a similar vaccine to melanoma patients.
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